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In humans, data from SARS and Middle East respiratory syndrome also showed that neurological injury in humans is rare, strongly suggesting that, normally, the BBB provides robust neuroprotection from viral CNS invasion in most patients 30

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The pineal glands release of melatonin into the bloodstream peaks in the evening, coinciding with nighttime darkness, and falls in the morning, stimulated by the onset of daylight

10.1146/annurev-physiol-042022-031925 35 XianX.XuM.YuH.WangL.LiX.RakJ.et al (2021)