Strinic D, Petrovic A, Balenovic D, et al
The presence of Nrf2 and its inhibitor Keap1 in plasma is associated with damaged vascular endothelial cell-, macrophage-and other cell-associated leakage secondary to the loss of cell membrane integrity due to lipid peroxidation following chronic inflammation and oxidative stress (Kasprzak et al., 2020), and Nrf2 and Keap1 in circulation are markers of severe inflammation and oxidative stress (Tu et al., 2019)
However, the study did not find significant associations with several common cardiac and metabolic disorders, including type 2 diabetes, hypertension, chronic kidney disease, ischemic heart disease, and congestive heart failure
This helps the heart muscle work more efficiently, especially under stress