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The role of ferroptosis in the metastatic niche (e.g., bone and lung metastases of RCC) is also unaddressedwhether the niches microenvironment (e.g., hypoxia and iron availability) modulates ferroptosis to support metastatic outgrowth requires clarification

Interestingly, in a study of drug nave first episode manic patients ( n = 56), serum ferritin was positively correlated with the BPRS (Brief Psychiatric Rating Scale) and YMRS (Young Mania Rating Scale) scores and patients showed higher inflammatory indices compared to their matched controls [127]

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Front Endocrinol (Lausanne) 13