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The upper arm will be cleaned and prepared and a small needle will be used to administer the B12 intramuscularly

During the apoptotic process, signaling cascades are activated, leading to a controlled death, and avoiding the uncontrolled release of parasites into the surrounding environment ( 2.2 Survival strategies of Leishmania inside macrophages Leishmania has evolved sophisticated ways to resist the array of microbicidal mechanisms generated by the macrophage, namely the oxidative stress, the recruitment of other immune cells and the process of apoptosis