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A 2008 study on muscle endurance and power in college varsity football players showed essentially no such benefit, while a small trial in cross-country runners three years later found no performance-enhancing benefits and one result that actually contradicted the claim made for the patch

Its effective for treating dry skin and as a supplemental measure for a variety of skin conditions

The additional N-terminal sequence and amino acid substitution are believed to support its biological activity by potentially increasing its affinity for IGF receptors while reducing its binding to proteins that may deactivate it (1)