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Tranexamic Acid : Helps to reduce the appearance of dark spots and prevent new ones from forming by inhibiting the interaction between melanocytes and keratinocytes

Lower levels might result in compromised detoxification, leading to an increased toxic load in the body

10,15,91 Of current interest is estetrol, which is a natural estrogen that spares the endometrium, while being an estrogen receptor agonist in the tissues, including the skin, that deteriorate following the loss of estradiol in the post-menopausal period

DECIPHER (v2.6.0) was used to align sequences, and FastTree (v2.1.3) was used to generate a phylogenetic tree