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WT mice was calculated for individual replicates, averaged, and converted to a log2 scale

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Proc Natl Acad Sci 100:94409445 Su YW, Chen X, Jiang ZZ, Wang T, Wang C, Zhang Y, Wen J, Xue M, Zhu D, Su YJ, Xing TY, Zhang CY, Zhang LY (2012) A panel of serum microRNAs as specific biomarkers for diagnosis of compound- and herb-induced liver injury in rats

Trials commonly began at a low once-weekly dose (around 0.25 mg) and escalated in roughly 4-week steps, with 2.4 mg once weekly being the most-studied maintenance example and doses up to 4.5 mg examined in dose-finding work