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When B12 levels are low, the signs can be varied: Anemia: fatigue, weakness, pale skin, and dizziness Fatigue: a deep-seated weariness that doesn't improve with rest Nerve Damage: tingling or numbness in hands and feet, balance problems, and memory loss (seek medical advice promptly) Mood Disturbances: depression, irritability, and personality changes Who Is Most at Risk for B12 Deficiency

, 18 , 313-329, doi: Lu, S

Typical values for HbA 1c measurement (using the previous standard Diabetes Control and Complications Trial, DCCT units of %) are shown in the Table below

In summary, the microbiome produces a pharmacopoeia of neuroactive compounds