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Another study has shown that the level of metabolites such as 2-methyl butyl carnitine, N-acetyl putrescine, amino butanal, carnitine, farnesyl diphosphate, shikimate and uridine were significantly higher in the cerebrospinal fluid (CSF) of GBM patients compared to the CSF of controls [190]

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24 Besides, NADPH acts as the reducing reagent for 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway, which leads to the synthesis of cholesterol and nonsterol isoprenoids

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