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Individuals with inborn errors of metabolism that affect homocysteine metabolism may require methionine-restricted diets and supplemental betaine and amino acids.21 CVD The American Heart Association recognizes hyperhomocysteinemia as an independent risk factor for CVD, atherosclerosis, stroke, thromboembolism, and myocardial infarction.7 Some research has demonstrated correlations between plasma homocysteine levels and the severity of atherosclerotic disease, as well as associations between hyperhomocysteinemia and increased risk of cardiovascular death

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doi: 10.1038/s41574-021-00593-z