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Plausible degradation pathways include: Serum aminopeptidases (cleaving from the N-terminus) Endopeptidases (internal bond cleavage) Hepatic uptake and degradation Renal clearance (though direct renal excretion of intact peptide of this size is typically limited) Whether BPC-157 generates active metabolites i.e., smaller peptide fragments that retain biological activity is not established in the public literature

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de Bari O, Wang HH, Portincasa P, Paik CN, Liu M, Wang DQ

Concurrently, the aberrant expression of iron metabolism-related genes, along with intracellular iron accumulationwhich is positively correlated with inflammatory responsescollectively promotes ferroptosis and subsequent tissue injury (27)