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Short-course studies report no overt toxicity at commonly used doses, but programs should include organ-system panels, cardiovascular telemetry where relevant, and pathology review for chronic exposures

GLP-1 receptor agonists like Saxenda (liraglutide, NICE TA664) and Wegovy (semaglutide, NICE TA875) may be considered for patients who meet specific criteria and have not achieved adequate weight loss with other interventions

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Death due to poisoning is caused by excessive cholinergic effects such as bronchospasms, hypersecretion from cholinergic innervated glands (especially critical in lungs and bronchi), and cardiac disturbances caused by vagotonus and anoxia