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The GWAS data for the 1400 metabolites were obtained from Chen et al.11 Abbreviations NAFLD: Non-Alcoholic Fatty Liver Disease GWAS: Genome-Wide Association Study FDR: False Discovery Rate LDSC: Linkage Unbalanced Regression cML-MA: Constrained Maximum Likelihood and Model Averaging OR: Odds Ratio HCC: Hepatocellular Carcinoma MR: Mendelian Randomization IVs: Instrumental Variables rRNA: Ribosomal Ribonucleic Acid IEU: Integrative Epidemiology Unit SNPs: Single Nucleotide Polymorphisms SE: Standard Error WM: Weighted Median IVW: Inverse Variance Weighted FMT: Fecal Microbiota Transplantation LDL: Low-Density Lipoprotein References Riazi K, Azhari H, Charette JH, Underwood FE, King JA, Afshar EE, et al

The clusterProfiler package of the R language was utilized to conduct enrichment analysis of drug target genes ( The keyword Chronic Obstructive Pulmonary Disease was retrieved using the ctd database ( and GeneCards database ( to predict COPD-related genes, and the intersected disease genes were obtained using the jvenn tool ( The STRING database ( was employed to retrieve a candidate gene with the Homo sapiens as defined species

Available online: 109.Zheng X., Zhang T., Ding H., Wang C

Enzyme activities involved in the glutamate-glutamine cycle are altered to reduce glutamate after spinal cord injury in rats