Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations As 2 O 3 : arsenic trioxide ROS: reactive oxygen species H 2 O 2 : hydrogen peroxide BSO: L-buthionine-sulfoximine GSH: glutathione L-PAM: melphalan SCID: severe combined immunodeficient CDDP: cis -diaminodichloro-platinum DOX: doxorubicin NAC: N -acetyl-L-cysteine DTT: dithiothreitol SOD: superoxide dismutase carboxy-PTIO: 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide LLC: Lewis lung carcinoma WST-8: 2-(2-methoxy-4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium monosodium salt CM-H 2 DCFDA: 5-(and-6)-chloromethyl-2,7-dichlorodihydrofluorescein diacetate DTNB: 5,5-dithiobis (2-nitrobenzoic acid GPX: GSH peroxidase GST: GSH- S -transferase TUNEL: terminal deoxynucleotidyl transferase-mediated nucleotide nick-end labeling References Segawa T, Takebayashi H, Kakehi Y, Yoshida O, Narumiya S and Kakizuka A (1998) Prostate-specific amplification of expanded polyglutamine expression: a novel approach for cancer gene therapy
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These target genes encompass a wide range of antioxidant enzymes and GSH synthesis-related genes, including the key System Xc component SLC7A11
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