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IL-4 also stimulates the release of eotaxin, which is an eosinophil chemoattractant

Moghaddasi, M., M

(4) Coding variants, with variants of deleterious or damaging predicted consequence in LD with GWAS PCOS signals, were scored 1.0 point, or only 0.5 points if the coding variants were predicted to be benign or tolerated

This "paradoxical response" (where treatment temporarily makes symptoms worse) includes: Numbness and tingling Shooting pains Joint pain Increased sensitivity Temporary inflammation (swelling and irritation) While these symptoms generally indicate that treatment is working (as nerves begin to repair themselves), they can be distressing for patients and may require additional treatment for comfort