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3 In April 2026, Health Canada authorized a generic semaglutide injection, which is a useful reminder that an approved synthetic peptide medicine is very different from an unauthorized compounded or online product

In the upstream, chronic hypertension and diabetes (both common in cSVD) have been shown to impair cerebral blood flow and oxygenation and promote an increase in BBB permeability

The mechanism involves stimulating over 300 different genes associated with tissue repair and remodeling, fibroblast activation and collagen synthesis, epidermal basal stem cell viability, an anti-inflammatory effect, an antioxidant effect and stimulation of microvascular growth

Meeting held at IARC, LYON, 714 june 1994