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Selenium, cadmium (Cd), arsenic (As), and lead (Pb) in particular have attracted a lot of study due to their complex relationships with thyroid function and trace elements [3]

In half of the reports assessing both males and females, only female animals exhibited an increase in activity, indicating potential sex-dependent differences

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Over the following decades, Pickart (who passed away in 2023 at age 85) and collaborators documented GHK-Cu's effects on wound healing, collagen production, hair growth, nerve outgrowth, and inflammation, building a substantial body of evidence that the peptide functions as a systemic tissue repair signal rather than having effects limited to any single tissue type