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Vitamin B12 is a water-soluble vitamin found only in food sources such as meat, eggs, dairy, and fish

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Escherichia coli, Streptococcus faecalis, Clostridium difficile and certain Salmonella species can bind Se from the body to their own enzymes to use amino acids instead of thiamine-containing amino acids, and can also convert the soluble form of Se to an insoluble form, making it unavailable for absorption by the body (114)

Furthermore, cysteamine has been recognized as an efficient depigmenting agent for melasma treatment (Qiu et al., 2000