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Its working mechanism is allosteric facilitation of HGF/c-Met signaling: Dihexa binds HGF with high affinity (reported K d ~65 pM in the original work) and is proposed to potentiate HGF dimerization and c-Met phosphorylation at subthreshold endogenous HGF concentrations
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Although doctors may recommend B12 injection for this purpose when weakness is related to peripheral neuropathy, more research is needed on effectiveness, and Medicare doesnt consider this medically necessary
Med Clin (Engl Ed)
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