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Minerva Endocrinol (2020) 45:32644

As a result, local inflammation develops, and activated immune cells and cytokines can affect other organs or trigger immune-related diseases, e.g., autoimmunity

Studies indicated that microbial dysbiosis in IgAN disrupts intestinal barrier integrity and metabolic balance, leading to the proliferation of pathogenic bacteria and a reduction in beneficial metabolism, thereby upsetting systemic immune homeostasis [142, 143]

Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of l-acetylcarnitine