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In 4 out of 11 patients ( i.e

The clinical trial data are consistent: IV protocols show 1522% melanin reduction over 812 weeks, oral protocols show 26% at best, and most oral users see no measurable change even after six months of daily supplementation

This would mean comparing their impacts on SLE-specific immunological biomarkers such as autoantibodies titers, complement proteins (C3, C4), cytokines such as IL-6, IL-10, and TNF-, and T cell subsets (especially the Th17/Treg ratio), to assess efficacy and monitor disease progression, and clinical manifestations

Further clinical studies are necessary to confirm efficacy and verify safety of the combination of L-carnitine and mandelic acid