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Interventions to reduce RAGE and RAGE ligand plasma and tissue levels, as tested in animal models, may offer novel approaches to slow or halt progression of CKD that develops in the absence, presence, or as a consequence of COVID-19

In the simplest caseand the most useful in designing drug dosage regimensthe body may be considered as a single compartment (as illustrated in Figure 32B) of a size equal to the volume of distribution (V)

Anyone considering these compounds should seek medical advice first and report any adverse reactions via the MHRA Yellow Card scheme

The use of metabolomics also opens the possibility of identifying some novel markers of forensic interest