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However, a direct comparison of these results was not possible due to a lack of congruence between the (a) age groups investigated, namely, clear-cut young and old groups (MRS (Emir et al., 2011, Hupfeld et al., 2021)) versus young + middle-aged and old groups (biochemical assay (Tong et al., 2016)), and/or (b) specific ROIs used: medial frontal (Hupfeld et al., 2021) versus prefrontal dorsolateral cortex (Tong et al., 2016), and occipital cortex (Emir et al., 2011) versus primary visual cortex (Tong et al., 2016)

They may cross-link structural proteins such as collagen, impair vasoreactivity, and promote oxidative and inflammatory signaling

Li L, Di X, Zhang S, Kan Q, Liu H, Lu T, et al

Tang R, Xu J, Zhang B, Liu J, Liang C, Hua J, et al