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Peer review Peer review information Nature Metabolism thanks Nigel Irwin, Michael Nauck and Brian Finan for their contribution to the peer review of this work

Of 73 patients treated with Amtagvi, 31.5% saw an objective response, with three experiencing a complete response and 20 a partial response

Sex differences in GSH and enzymes involved in its metabolism have been reported in healthy individuals [87], patients with AD [51], infants [88], and several animal models [89,90,91]