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Toxic megacolontotal or segmental nonobstructive dilatation of the colon with systemic toxicity in patients with IBD or infectious colitis Laboratory values of acute phase reactants, including the erythrocyte sedimentation rate and C- reactive protein, can be increased but may also be normal in mildly active disease

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Retatrutide has one of the longest plasma half-lives on this peptide half-life chart at approximately 6 days, followed closely by Semaglutide at roughly 7 days and Tirzepatide at about 5 days