In conclusion, mitophagy plays a pivotal role in cardiomyocyte hypertrophy and fibrosis, the progression of oxidative stress, inflammation, and cardiomyocyte death
Advanced (Weeks 9-12) Dose : 500 mcg subQ (split 250 mcg AM/PM) Frequency : Twice daily Duration : 8-12 weeks, monitored For metabolic resistance
Intermittent episodes occur with poor sleep hygiene or psychosocial stressors
Modern studies have reported that Ganoderma polysaccharides, as its core active metabolites, can exert antioxidant and neuroprotective effects by inhibiting mitochondrial oxidative stress ( in vivo experimental study based on rat HH test model has reported that the aqueous extract of Ganoderma lucidum can improve neurotransmitter levels in HH animal models, prevent the surge of glucocorticoids and -synuclein, induce the upregulation of CREB/p-CREB/BDNF expression through ERK1/ERK2 to improve synaptic plasticity, and maintain redox homeostasis, to improve HH-related spatial memory deficits and neuronal damage ( Ganoderma lucidum and its active metabolites, through multi-dimensional regulation of neurotransmitter networks, oxidative stress responses, and synaptic remodeling, may provide a potential intervention strategy for HACE-induced cognitive dysfunction and brain tissue damage
