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In the brain increased VEGF activity is noted after damage or trauma, which increases angiogenesis [12, 143]

For example, researchers have tested BPC-157 enemas as a treatment for ulcerative colitis in a pair of clinical trials conducted by the Croatian pharmaceutical company PLIVA in the 2000s

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[10] These are the most speculative extensions of the systemic story: they rest on gene-signature matching and in-vitro observations, and they should be read as directions researchers find interesting rather than as demonstrated systemic effects