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Other B vitamins, such as riboflavin and vitamin B6 also play an important role

Levels in exercise: Although they both decline with age, those who exercise are more likely to have higher humanin but lower MOTS-c than those who do not exercise [26]

Furthermore, by reducing CCO activity and compromising oxidative phosphorylation, copper deficiency compels cardiomyocytes to rely more heavily on anaerobic glycolysis, thereby reinforcing the metabolic shift that underpins pathological reprogramming [104]