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Dysfunction of ocular structures and various systemic diseases, environmental factors, and living habits, such as long-term wearing of contact lenses, can lead to the occurrence and development of DED (302)

Genetic factors that affect nonalcoholic fatty liver disease: a systematic clinical review

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have provided evidence that tofacitinib directly modulates mitochondrial function, such as regulating key mitochondrial genes, increasing oxidative phosphorylation, enhancing ATP production while diminishing glycolytic flow and key glycolytic genes (162)