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Its all fitting with the overriding idea that changes in synaptic strength are part of the way these drugs motivate behavior in a persistent way, McGehee said

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It is already well-known that the brains of long-term alcoholics atrophy and shrink, the study authors say, but the new findings are the first evidence that cigarette smoking might contribute to that atrophy, particularly in grey matter of the parietal and temporal lobes