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The risk of progressing from controlled use of psychoactive drugs to compulsive and uncontrolled drug-use behaviors that characterize addiction is especially high in individuals who have pre- and/or co-morbid pathology, such as the presence of psychiatric disorders like depression, anxiety, and obsessive-compulsive disorder, according to a 2015 article by Christian P

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[54] [55] Psychonautics [edit source] The aims and methods of psychonautics, when state-altering substances are involved, is commonly distinguished from recreational drug use by research sources