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However, upon release in the hydrophilic cytoplasm, the fluorescence of the dye is quenched, allowing for the facile detection of the degradation of the nanoparticles
Across platforms, metabolite measurements demonstrated consistent cross-platform behavior, with 50% of metabolites showing both high correlation and quantitative agreement, and a smaller subset (7%) exhibiting strong correlation but systematic differences in absolute quantification ( Figure S1E)
