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Malignant cells also need to degrade ECM in order to metastatize and this comes about by the release of metalloproteinases (MMPs) that are also regulated by miRNAs

Enzyme Activation Lysyl oxidase, the enzyme responsible for cross-linking collagen and elastin fibers (essential for tissue strength, elasticity, and proper matrix organization), absolutely requires copper as a cofactor - GHK-Cu enhances lysyl oxidase activity by ensuring adequate copper availability, thereby promoting proper collagen and elastin maturation and tissue structural integrity